A press release came out today from Pfizer and Binotech with a very exciting announcement, but what does it say? Andrea shares her insights.
This is the coronavirus SARS-CoV-2.
The coronavirus consists mainly of large protein molecules, which make up the virus hull and the protruding spikes, which allow it to infect a host cell.
Inside of SARS-CoV-2 is the RNA - blueprints for more molecules which, once a human cell is infected, hijack the cell to produce new copies of the virus.
If we understand these molecules, we cannot only learn how the virus works, but may also find a cure. Antibodies (produced from vaccines) and small molecules (drugs) both bind to these protein macromolecules like keys to a lock and can deactivate them.
The Coronavirus Structural Task Force evaluates the molecular structures from Coronavirus, improves them by pushing the structural biology methods to their limit and puts these structures into context for drug developers and other scientists.
Exoribonuclease is a domain of nsp14 responsible for chopping out nucleotides incorrectly added by RdRp. This enzyme allows the large 29.9 kb genome of SARS-CoV-2 and remains a worthwhile target for drugs to fight this virus.
COVID-19 is caused by the new coronavirus SARS-CoV-2. This virus has a characteristic virus hull featuring surface proteins which are commonly called “spikes”. Protruding from the viral hull like “spikes of a crown”, they give the coronavirus its name (corona = crown). These proteins make the first contact with human cells and are akin to […]
It has been said that a lie can travel half way around the world while the truth is putting its shoes on. This article looks into the claims that SARS-CoV-2 was produced in a lab and presents the science that has now had time to put on its shoes.
How are the structures of proteins measured? Which common methods are there? What Data do you get?