Coronavirus
Structural Task Force

Sabrina Stäb

Biochemistry M.Sc. student

Sabrina is studying biochemistry (M.Sc.) and works as a research assistant in the Thorn lab in Würzburg. During her bachelor thesis on "Crystallization and structure solution of high-quality structures for MAD experiments", she was able to gain a lot of experience in the field of crystallography and now brings this experience to the project. When she doesn't have to stay at home because of corona, she likes to spend her free time with friends or in the forest picking mushrooms.

Posts of Sabrina Stäb

Picture of corona virus main protease structure with labels.

3C-like Protease: A Promising Drug Target

by
Sabrina Stäb
on
April 7, 2020
Due to a new outbreak of pulmonary diseases caused by SARS-CoV-2, the development of new drugs is essential to contain the COVID-19 pandemic. One promising drug target is the 3C-like protease, also known as main protease or MPro. Most of the virus proteins are translated as one long polypeptide chain, which then has to be […]

Spike Glycoprotein: The Key to Invade the Host Cell

by
Sabrina Stäb
on
May 12, 2020
Overview The surface proteins, also called the “spike” or S-proteins, protrude from the viral envelope of SARS-CoV-2 like “spikes of a crown”, thus giving the coronavirus its name. They mediate entry into the host cell by binding to a cellular receptor called angiotensin-converting enzyme (ACE2), triggering a cascade of events leading to membrane fusion and […]

Spike Glycoprotein: Corona’s Key for Invasion

by
Sabrina Stäb
on
June 5, 2020
COVID-19 is caused by the new coronavirus SARS-CoV-2. This virus has a characteristic virus hull featuring surface proteins which are commonly called “spikes”. Protruding from the viral hull like “spikes of a crown”, they give the coronavirus its name (corona = crown).  These proteins make the first contact with human cells and are akin to […]

Accessory Protein 7a: Key Role in Pathogenesis?

by
Sabrina Stäb
on
October 30, 2020
The genome of the novel SARS-CoV-2 codes for an ORF1a/ ORF1ab (open reading frame) polyprotein containing sixteen non-structural proteins (NSP) and four structural proteins. The genome also has multiple ORFs coding for accessory proteins through a frame shift. These accessory proteins are not necessary for viral replication but might play a key role in pathogenesis […]
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