| Abbreviation | Explanation |
| 2'-o-MT | 2'-O-ribose methyltransferase |
| 3CLpro | SARS-CoV-2 3C-like protease, also known as 3C-like proteinase, main protease, NSP5A_3CLpro and NSP5B_3CLpro, Mpro |
| 3Ecto | NSP3 ecto domain |
| Ac1 | the N-terminal acidic domain of NSP3 |
| ACE2 | angiotensin-converting enzyme 2 |
| ADPr | ADP-ribose |
| ADRP | ADP-ribose 1"-phosphate phosphatase |
| ARDS | acute respiratory distress syndrome |
| ARI | acute respiratory infection |
| ARTD | ADP-ribosyltransferases diphtheria toxin-like |
| BCoV | bovine corona virus |
| CM | convoluted membrane |
| CoV | coronavirus |
| CTD | the C-terminal domain of N-protein (a.a. 248–365) |
| DD | the di-domain of N-protein comprising NTD, LKR and CTD (a.a. 45–365) |
| DMV | double membrane vesicle |
| DPUP | domain preceding UBL2 and PL2pro |
| DUB | deubiquitinating enzyme |
| E | envelope protein, E-protein |
| ER | endoplasmatic reticulum |
| ERGIC | ER–Golgi intermediate compartment |
| ESCRT | endosomal sorting complex required for transport |
| ExoN | exonuclease, exoribonuclease |
| GFL | growth factor-like protein, NSP10 |
| GST | glutathione S-transferase |
| HCoVOC43 | human coronavirus OC43 |
| HEL | helicase, helicase domain |
| HVR | hypervariable region |
| IBV | infectious bronchitis virus |
| IL-6 | interleukin 6 |
| IRF | interferon regulatory factor |
| Mac | macrodomain |
| MARylation | mono-ADP-ribosylation |
| MERS | Middle East respiratory syndrome |
| MHV | mouse hepatitis virus |
| mISG15 | mouse interferon-stimulated gene 15 |
| Mpro | SARS-CoV-2 main protease, also known as 3C-like protease, 3C-like proteinase, NSP5A_3CLpro and NSP5B_3CLpro, main protease, or Mpro |
| MTase | methyltransferase |
| N | nucleocapsid protein |
| N7-MTase | guanine-N7-methyltransferase |
| NAB | nucleic acid-binding domain |
| NendoU | Nidovirales endoRNAse, uridylate-specific endoribonuclease NendoU |
| NF-κB | nuclear factor kappa-light-chain-enhancer of activated B cells |
| NiRAN | RNA-dependent RNA polymerase, NSP7 |
| NSP | non-structural protein |
| NSP1 | non-structural protein 1, SARS-CoV-2 leader protein |
| NSP10 | non-structural protein 10, growth factor-like protein, GFL |
| NSP13-PP1ab | non-structural protein 13 |
| NSP14A2_ExoN | SARS-CoV-2 3'-to-5' exonuclease, non-structural protein 14 |
| NSP14B_NMT | SARS-CoV-2 guanine-N7-methyltransferase, non-structural protein 14 |
| NSP15-A1 | SARS-CoV-2 endoRNAse, also known as NSP15B-NendoU and NendoU, uridylate-specific endoribonuclease NendoU |
| NSP15B-NendoU | SARS-CoV-2 endoRNAse, also known as NSP15-A1 and NendoU, uridylate-specific endoribonuclease NendoU |
| NSP3 | non-structural protein 3 |
| NSP5A_3CLpro | non-structural protein 5, SARS-CoV-2 3C-like protease, also known as 3C-like proteinase, main protease, 3CLpro, Mpro |
| NSP7 | non-structural protein 7 |
| NSP9 | non-structural protein 9, ssRNA-binding protein |
| NTD | N-terminal domain |
| ORF | open reading frame |
| ORF1ab | papain-like protease, PLpro, or open reading frame polyprotein 1ab |
| PABP | poly(A)-binding protein |
| PARP | poly (ADP-ribose) polymerase |
| PARylation | poly ADP-ribosylation |
| PDM | PDZ-binding motif (in E-protein) |
| PIKfyve | FYVE finger-containing phosphoinositide kinase |
| PLpro | papain-like protease, ORF1ab |
| pp | polyprotein |
| RCHY1 | RING finger and CHY zinc finger domain-containing protein 1 |
| RdRp | RNA-dependent RNA polymerase, NSP12 |
| RID | Ras-interacting domain |
| RTC | replication–transcription complex |
| S | spike protein, surface glycoprotein, E2 glycoprotein |
| SARS | severe acute respiratory syndrome |
| SARS-CoV | severe acute respiratory syndrome coronavirus |
| SARS-CoV-2 | coronavirus causing COVID-19 |
| ssRNA | single-stranded RNA |
| SUD | SARS-unique domain |
| TCP2 | transcription factor 2 |
| TM | transmembrane (domain) |
| TMD | transmembrane domain |
| TMPRSS2 | transmembrane protease serine 2 |
| TNF | tumor necrosis factor |
| TPC2 | two-pore channel subtype 2 |
| TRS | transcriptional regulatory sequence |
| UBL | ubiquitin-like |
| UBL1 | ubiquitin-like domain 1 |
| USP | ubiquitin-specific protease |
| UTR | untranslated region |
| VLP | virus-like particle |
| ZD | zinc-binding domain |
| βSM | betacoronavirus-specific marker |
