Coronavirus
Structural Task Force

Glossary

AbbreviationExplanation
2'-o-MT2'-O-ribose methyltransferase
3CLpro  SARS-CoV-2 3C-like protease, also known as 3C-like proteinase, main protease, NSP5A_3CLpro and NSP5B_3CLpro, Mpro
3EctoNSP3 ecto domain
Ac1the N-terminal acidic domain of NSP3
ACE2angiotensin-converting enzyme 2
ADPrADP-ribose
ADRPADP-ribose 1"-phosphate phosphatase
ARDSacute respiratory distress syndrome
ARIacute respiratory infection
ARTDADP-ribosyltransferases diphtheria toxin-like
BCoVbovine corona virus
CMconvoluted membrane
CoVcoronavirus
CTDthe C-terminal domain of N-protein (a.a. 248–365)
DDthe di-domain of N-protein comprising NTD, LKR and CTD (a.a. 45–365)
DMVdouble membrane vesicle
DPUPdomain preceding UBL2 and PL2pro
DUBdeubiquitinating enzyme
Eenvelope protein, E-protein
ERendoplasmatic reticulum
ERGICER–Golgi intermediate compartment
ESCRTendosomal sorting complex required for transport
ExoNexonuclease, exoribonuclease
GFLgrowth factor-like protein, NSP10
GSTglutathione S-transferase
HCoVOC43human coronavirus OC43
HELhelicase, helicase domain
HVRhypervariable region
IBVinfectious bronchitis virus
IL-6interleukin 6
IRFinterferon regulatory factor
Macmacrodomain
MARylationmono-ADP-ribosylation
MERSMiddle East respiratory syndrome
MHVmouse hepatitis virus
mISG15mouse interferon-stimulated gene 15
MproSARS-CoV-2 main protease, also known as 3C-like protease, 3C-like proteinase, NSP5A_3CLpro and NSP5B_3CLpro, main protease, or Mpro
MTasemethyltransferase
Nnucleocapsid protein
N7-MTaseguanine-N7-methyltransferase
NABnucleic acid-binding domain
NendoUNidovirales endoRNAse, uridylate-specific endoribonuclease NendoU
NF-κBnuclear factor kappa-light-chain-enhancer of activated B cells
NiRANRNA-dependent RNA polymerase, NSP7
NSPnon-structural protein
NSP1non-structural protein 1, SARS-CoV-2 leader protein
NSP10non-structural protein 10, growth factor-like protein, GFL
NSP13-PP1abnon-structural protein 13
NSP14A2_ExoNSARS-CoV-2 3'-to-5' exonuclease, non-structural protein 14
NSP14B_NMTSARS-CoV-2 guanine-N7-methyltransferase, non-structural protein 14
NSP15-A1SARS-CoV-2 endoRNAse, also known as NSP15B-NendoU and NendoU, uridylate-specific endoribonuclease NendoU
NSP15B-NendoUSARS-CoV-2 endoRNAse, also known as NSP15-A1 and NendoU, uridylate-specific endoribonuclease NendoU
NSP3non-structural protein 3
NSP5A_3CLpronon-structural protein 5, SARS-CoV-2 3C-like protease, also known as 3C-like proteinase, main protease, 3CLpro, Mpro
NSP7non-structural protein 7
NSP9non-structural protein 9, ssRNA-binding protein
NTDN-terminal domain
ORFopen reading frame
ORF1abpapain-like protease, PLpro, or open reading frame polyprotein 1ab
PABPpoly(A)-binding protein
PARPpoly (ADP-ribose) polymerase
PARylationpoly ADP-ribosylation
PDMPDZ-binding motif (in E-protein)
PIKfyveFYVE finger-containing phosphoinositide kinase
PLpropapain-like protease, ORF1ab
pppolyprotein
RCHY1RING finger and CHY zinc finger domain-containing protein 1
RdRpRNA-dependent RNA polymerase, NSP12
RIDRas-interacting domain
RTCreplication–transcription complex
Sspike protein, surface glycoprotein, E2 glycoprotein
SARSsevere acute respiratory syndrome
SARS-CoVsevere acute respiratory syndrome coronavirus
SARS-CoV-2coronavirus causing COVID-19
ssRNAsingle-stranded RNA
SUDSARS-unique domain
TCP2transcription factor 2
TMtransmembrane (domain)
TMDtransmembrane domain                   
TMPRSS2transmembrane protease serine 2
TNFtumor necrosis factor
TPC2two-pore channel subtype 2
TRStranscriptional regulatory sequence
UBLubiquitin-like
UBL1ubiquitin-like domain 1
USPubiquitin-specific protease
UTRuntranslated region
VLPvirus-like particle
ZDzinc-binding domain
βSMbetacoronavirus-specific marker

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Coronavirus Structural Taskforce
Universität Hamburg
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