Entry of virus
Infection with SARS-CoV-2 starts upon entry into the host cell via glycosylated spike proteins, which attach to the host cell receptor angiotensin-converting enzyme 2 (ACE2).
After attachment, SARS-CoV-2 enters the host cell via endocytosis or fusion at the plasma membrane, which is driven by protease cleavage and activation.
SARS-CoV-2 then releases its genomic RNA (positive sense) into the cytosol of the host cell for viral RNA and protein synthesis.
More about the virus hull
More about the spike