This database provides the macromolecular models for 17 of the 28 different SARS-CoV and SARS-CoV-2 proteins, as well as structures of the most important human coronavirus interaction partners. The database contains hundreds of experimentally determined macromolecular structures - original files as well as newly processed and modelled structures.
All structures have been evaluated and some have been reviewed manually, atom by atom. If we were able to achieve a significant improvement some of the structures in the process, and those improved models can also be found in the database. Of course, this is not a criticism of the outstanding achievements of the original authors; it is about pushing the limits of our modern methods to extract every bit of biological information possible.
What is the database for?
It is intended to serve as a public global resource for the macromolecular structures of SARS-CoV and SARS-CoV-2 coronaviruses. Researchers can make use of our findings to better understand the biology of the viral lifecycle and use specific structures for bioinformatics structures, as well as to develop drugs against COVID-19 as quickly as possible.
The data can be accessed through the GitHub repository. The nature of the data and more information can be found here.
Link: https://insidecorona.net/de/auf-github/
The procedures and explanations concerning our research can be found in "The Procedure". Choosing the Right Structure gives help on evaluating structures and Quality Indicators gives an overview of common criteria.
If want to see how we work, you can visit our Twitch channel:
https://www.twitch.tv/taskforcec19
The table as JSON file:
https://github.com/thorn-lab/coronavirus_structural_task_force/blob/master/utils/stats.json
